Vaccines against gut pathogens

Vaccines against dangerous pathogens.

Dangerous pathogens are defined by the UK Health and Safety Executive's advisory committee as category 3 (those which cause severe human disease for which prophylaxis or therapy is usually available) or category 4 (as for category 3, but for which prophylaxis or therapy is not available). Research and development of vaccines for such pathogens is challenging, due to the safety constraints in th...

Epitope Driven Broad Spectrum Peptide Vaccines against MDR Pathogens

Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumonia have evolved as a group of co-existing multidrug resistant nosocomial pathogens spreading worldwide. Overuse of antibiotics has led to the emergence of pan drug resistant bacterial strains and has made all antimicrobial agents superfluous including carbapenems and even the last resort antibiotic-colistin, resulting in high...

Genome-based approaches to develop vaccines against bacterial pathogens.

Bacterial infectious diseases remain the single most important threat to health worldwide. Although conventional vaccinology approaches were successful in conferring protection against several diseases, they failed to provide efficacious solutions against many others. The advent of whole-genome sequencing changed the way to think about vaccine development, enabling the targeting of possible vac...

Editorial: Why Vaccines to HIV, HCV, and Malaria Have So Far Failed—Challenges to Developing Vaccines Against Immunoregulating Pathogens

Together with sanitation, vaccination is one of the most effective life-saving interventions available in the fight against infectious diseases. As you read this issue of Frontier in Microbiology, scientists around the globe are working toward developing vaccines against diverse infectious diseases, allergies, cancer and autoimmune diseases. We believe that every major disease will eventually h...

Studies on development of vaccines against pathogens causing sexually transmitted infections